Biomolecules Review: Activities for the High School Classroom
I present biomolecules as a cornerstone that we come back to again and again in my biology class. Why not? Biomolecules are the building blocks of life, essential for the structure, function, and regulation of living organisms. The problem is that presenting biomolecules review activities for high school can sometimes be challenging. It feels abstract to many students and as if it doesn’t have anything to do with them.
To make the learning experience more interactive and engaging, incorporating hands-on activities and games can significantly enhance students’ comprehension. In this blog post, I’ll explore a range of activities for your biomolecules lesson plan from needing nothing but your imagination to a full lab.
Demos & Hooks Biomolecules Activities
I like to figure out a way to make the content we are moving into something interesting. It can be daunting with the chemistry section of biology. This is where I like to have food. Assuming that you can let the kids safely have a snack, this is the way to a high schooler’s heart. In fact, I conduct an entire lab using food. Connecting biomolecules to food they eat and the nutrition and energy their body needs.

Some rainbow candy fun packs or other Halloween/Easter candy that has either has a nutrition label on it OR that you can project for students to see will be beneficial. Handing out the snack while the kids enter with the nutrition label projected (or instructions to take note of the nutrition label) will probably be enough to pique their interest at least a little.
Mythbusting Biomolecules Activity
Another good one is dissolving pudding. Most students equate protein and muscle. They don’t think about protein having many different roles. Introduce a pudding cup. Tell them you are going to add a specific type of protein and have them predict what will happen. Add a digestive enzyme packet (or open a capsule and poor into the protein) mix and it will become liquified. You have just busted the misconception that proteins are always building blocks for muscles. Proteins can also have a functional or active role.

Macromolecules Lab:
Make time for a hands-on activity where students can explore macromolecules. I love to use a popular snack food, but you can choose what you want. I like to do labs where students get to really dig and explore the concept. Students can perform tests to identify the macromolecules, such as iodine for starch or Benedict’s solution to test for reducing sugars, the Sudan III test for lipids, the Biuret test for proteins, and the DNA extraction experiment. I have a lab I use in my shop. I go into more detail about lab in my macromolecules lab blog post. This activity will enable students to observe the characteristics and properties of macromolecules firsthand. It is also ties the nutrition label, energy usage, and biomolecules together. You can also grab this on TPT.

Biomolecules Concept Map, Graphic Notes, and Worksheets
A comprehensive biomolecules review is essential to solidify students’ understanding of the topic. Develop a review sheet or worksheet that covers the main biomolecule types, including carbohydrates, lipids, proteins, and nucleic acids. Include questions that address the structure, function, and examples of each biomolecule. This review can serve as a valuable resource for students to study and reinforce their knowledge. I recently switched to sketch notes for more biology I class.

Biomolecules Interactive Activities:
Repetition and recall are always on my mind. I like using learning stations as interactive activities. Learning stations can include traditional wet lab work, but there are lots of other options. Lab simulations, interactive presentations, videos, articles, vocabulary work, case studies, sorting cards, and task cards are all great additions to learning stations. I personally love rotating learning stations because they are already familiar with rotating centers from elementary and it gives kids a chance to get up and stretch.

Task cards are a versatile tool that promotes active learning and critical thinking. Some of the same benefits of a workshop with more engagement and potential. Use a set of task cards that cover various aspects of biomolecules. Include questions that require students to identify biomolecules based on their description or function or analyze their role in biological processes. Students can work individually or in groups, encouraging discussion and collaboration.
I like to provide student record sheets for task cards. These resources allow students to self-assess their understanding and reinforce correct information. Additionally, answer sheets enable teachers to provide prompt feedback. Immediately correcting any misconceptions.
I have a set ready for you to use that includes digital, PDF, and editable PowerPoint files.
You can also grab these on TPT.
Biomolecules Games:
Introduce interactive games to make biomolecule learning enjoyable. Utilize PowerPoint or Google Slides to create games. I actually have my task cards already formatted as a game to use either in small groups or as a large group.
That isn’t the only option. Grab my easy bingo boards to create a biomolecules bingo game. Another option is a “Jeopardy-style” game, where students compete in teams, answering questions related to biomolecules. These games promote friendly competition, active participation, and retention of knowledge.

You can grab these on TPT.
Benefits of using these Resources in your Biomolecules Review:
The ideas discussed in this blog post offer benefits to you and your students. Starting with the ready-to-print option makes it easy for you to print and go. Less prep means more time teaching. Many of these ideas can be adapted for different learning needs and most the resources referenced include edible options.
If you want to grab the resources, save $$$ with the bundle. My bundles are 30% off the individual prices.
Looking for other ideas for teaching high school biology? Make sure to check out the Biology Lesson Plans post.


